Tarafenacin D-tartrate

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Chemical Structure| 1159101-48-0 同义名 : SVT-40776 D-tartrate
CAS号 : 1159101-48-0
货号 : A707818
分子式 : C25H26F4N2O8
纯度 : 98+%
分子量 : 558.476
MDL号 : -
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(188.01 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Tarafenacin D-tartrate is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.79mL

0.36mL

0.18mL

8.95mL

1.79mL

0.90mL

17.91mL

3.58mL

1.79mL
参考文献

[1]Huang X, Zheng G, et al. Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation. J Phys Chem B. 2012 Jan 12;116(1):532-41. doi: 10.1021/jp210579b. Epub 2011 Dec 20.

[2]Salcedo C, Davalillo S, et al. In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Br J Pharmacol. 2009 Mar;156(5):807-17.