产品说明书

MK2-IN-3 hydrate

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Chemical Structure| 1186648-22-5 同义名 : MK2 Inhibitor III
CAS号 : 1186648-22-5
货号 : A699021
分子式 : C21H18N4O2
纯度 : 95+%
分子量 : 358.393
MDL号 : MFCD28143748
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(334.83 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MK2-IN-3 hydrate is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) with an IC50 of 0.85 nM. MK2-IN-3 hydrate is effective against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1 (IC50=5.7 μM), CDK2, JNK2, IKK2, MSK1 and MSK2, confirming its selectivity. MK2-IN-3 hydrate can inhibit the production of TNFα in U397 cells, with an IC50 of 4.4 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.95mL

2.79mL

1.40mL

27.90mL

5.58mL

2.79mL
参考文献

[1]Anderson DR, et al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.