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Salvianolic acid A

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Chemical Structure| 96574-01-5 同义名 : Salvianolic Acid;Dan Phenolic Acid A
CAS号 : 96574-01-5
货号 : A695449
分子式 : C26H22O10
纯度 : 99%+
分子量 : 494.447
MDL号 : MFCD08458447
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(171.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Salvianolic acid A (Sal A or SAA) is a hydrophilic polyphenolic derivative isolated from Salvia miltiorrhiza Bunge as an anti-cancer and cardio-protective herbal medicine. The IC50 values were determined as 5.7 µM in the HEK293/ETAR cell line and 3.14 µM in HeLa cells, respectively[3]. in vitro, SAA enhances the activation of the Akt/GSK-3β/Nrf2 signaling pathway in H2O2-Induced HK-2 Cells. in vivo, administration of SAA significantly increased the activities of T-SOD, GPx, and CAT[4]. It also can inhibit platelet activation via the inhibition of PI3K, and attenuates arterial thrombus formation in vivo, suggesting that it may be developed as a therapeutic agent for the prevention of thrombotic disorders[5]. Salvianolic acid A is also a matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats, and inhibits PDGF-BB-activated HSC proliferation, partially through apoptosis induction while exerting no direct cytotoxicity on primary hepatocytes and HSC-T6 cells under experimental concentrations[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.11mL

2.02mL

1.01mL

20.22mL

4.04mL

2.02mL
参考文献

[1]Wang X, Wang C, et al. Salvianolic acid A shows selective cytotoxicity against multidrug-resistant MCF-7 breast cancer cells. Anticancer Drugs. 2015 Feb;26(2):210-23.

[2]Cai J, Chen S, et al. Salvianolic acid A reverses paclitaxel resistance in human breast cancer MCF-7 cells via targeting the expression of transgelin 2 and attenuating PI3 K/Akt pathway. Phytomedicine. 2014 Oct 15;21(12):1725-32.

[3]Zhang Q, Wang S, Yu Y, et al. Salvianolic Acid A, as a Novel ETA Receptor Antagonist, Shows Inhibitory Effects on Tumor in Vitro. Int J Mol Sci. 2016;17(8):1244. Published 2016 Aug 2.

[4]Zhang HF, Wang JH, Wang YL, et al. Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats. Oxid Med Cell Longev. 2019;2019:2853534. Published 2019 Mar 18.

[5]Huang ZS, Zeng CL, Zhu LJ, Jiang L, Li N, Hu H. Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of phosphoinositide 3-kinase. J Thromb Haemost. 2010;8(6):1383-1393.

[6]Jiang B, Li D, Deng Y, et al. Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats. PLoS One. 2013;8(3):e59621.