Cilostamide

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Chemical Structure| 68550-75-4 同义名 : OPC3689
CAS号 : 68550-75-4
货号 : A687688
分子式 : C20H26N2O3
纯度 : 99%+
分子量 : 342.432
MDL号 : MFCD00673958
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(87.61 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cilostamide is a selective and potent inhibitor of PDE3, with IC50 values of 27 nM for PDE3A and 50 nM for PDE3B, exhibiting anti-thrombotic and anti-neointimal proliferation activities. It weakly inhibits PDE2, PDE4, PDE5, PDE7, and PDE1, with IC50 values of 12.5 μM, 88.8 μM, 15.2 μM, 22.0 μM, and > 300 μM, respectively. Cilostamide effectively inhibits thrombin-induced platelet aggregation with an IC50 of 1.1 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.92mL

0.58mL

0.29mL

14.60mL

2.92mL

1.46mL

29.20mL

5.84mL

2.92mL
参考文献

[1]Sudo T, et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem Pharmacol. 2000 Feb 15;59(4):347-56.