PD184161

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Chemical Structure| 212631-67-9 同义名 : -
CAS号 : 212631-67-9
货号 : A685594
分子式 : C17H13BrClF2IN2O2
纯度 : 99%+
分子量 : 557.556
MDL号 : MFCD16038897
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(188.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PD184161 is an orally active MEK inhibitor. It inhibits MEK activity in a time- and concentration-dependent manner with an IC50 ranging from 10 to 100 nM. PD184161 suppresses cell proliferation and induces apoptosis. It also produces antidepressant-like behaviors[1][2]. PD184161 inhibits cell proliferation and induces apoptosis in a time- and concentration-dependent manner within the concentration range of 1-20 μM, over time periods of 24, 48, or 72 hours. PD184161 (0.1 and 1.0 μM; 1 hour) inhibits the phosphorylation of ERK1,2[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.79mL

0.36mL

0.18mL

8.97mL

1.79mL

0.90mL

17.94mL

3.59mL

1.79mL
参考文献

[1]Klein PJ, et al. The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer. Neoplasia. 2006 Jan;8(1):1-8.

[2]Duman CH, et al. A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment. Biol Psychiatry. 2007 Mar 1;61(5):661-70.

[3]Gladbach A, et al. ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke. J Neural Transm (Vienna). 2014 May;121(5):543-7.