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GB-88

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Chemical Structure| 1416435-96-5 同义名 : -
CAS号 : 1416435-96-5
货号 : A669532
分子式 : C32H42N4O4
纯度 : 99%+
分子量 : 546.7
MDL号 : MFCD29920338
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(54.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GB-88 is an orally active, selective non-peptide PAR2 antagonist that inhibits PAR2-activated Ca2+ release with an IC50 of 2 µM[1].GB-88 inhibits iCa2+ release induced by trypsin, 2f-LIGRLO-NH2 and GB110 (PAR2 agonist) in HT29 cells. The antagonistic effect of GB-88 is agonist dependent[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.15mL

1.83mL

0.91mL

18.29mL

3.66mL

1.83mL
参考文献

[1]Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012 Mar;165(5):1413-23.