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Dendrobine

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Chemical Structure| 2115-91-5 同义名 : (–)-Dendrobine
CAS号 : 2115-91-5
货号 : A664519
分子式 : C16H25NO2
纯度 : 99%
分子量 : 263.375
MDL号 : MFCD17676142
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(132.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Dendrobine, a natural product isolated and purified from the herb of Dendrobium nobile Lindl., is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord, has antitumor activity,can inhibit the growth of A549 cells through inducing apoptosis, which is partially dependent on mitochondrial-mediated pathway, and possesses antiviral activity against influenza A viruses, including A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1), and A/Aichi/2/68 (H3N2) with IC50 values of 3.39 ± 0.32, 2.16 ± 0.91, 5.32 ± 1.68 ug/mL, respectively. Dendrobine treatment decreases mitochondrial membrane potential (MMP), and improves the expression of Bax and inhibited the expression of Bcl-2.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.80mL

0.76mL

0.38mL

18.98mL

3.80mL

1.90mL

37.97mL

7.59mL

3.80mL
参考文献

[1]Li R, Liu T, et al. Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action. J Agric Food Chem. 2017 May 10;65(18):3665-3674.

[2]Kudo Y, Tanaka A, Yamada K. Dendrobine, an antagonist of beta-alanine, taurine and of presynaptic inhibition in the frog spinal cord. Br J Pharmacol. 1983 Apr;78(4):709-15.