产品说明书
ML346
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同义名 : | - |
| CAS号 : | 100872-83-1 | |
| 货号 : | A638881 | |
| 分子式 : | C14H12N2O4 | |
| 纯度 : | 98% | |
| 分子量 : | 272.256 | |
| MDL号 : | MFCD01177921 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 12 mg/mL(44.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | ML346 is an activator for both Hsp70 expression and HSF-1 activity, achieving an EC50 value of 4.6 μM specifically for Hsp70. It has demonstrated the ability to aid in protein folding within models of conformational diseases, doing so without significant cytotoxic effects or a loss of specificity. ML346 notably causes increases in certain genes and proteins that are part of the heat shock response (HSR), including chaperones like Hsp70, Hsp40, and Hsp27[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.67mL 0.73mL 0.37mL |
18.37mL 3.67mL 1.84mL |
36.73mL 7.35mL 3.67mL |
| 参考文献 |
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