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PF-04856264

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Chemical Structure| 1235397-05-3 同义名 : -
CAS号 : 1235397-05-3
货号 : A633501
分子式 : C20H15N5O3S2
纯度 : 95%
分子量 : 437.495
MDL号 : MFCD28124397
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(571.44 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PF-04856264 acts as a potent and selective Nav1.7 channel inhibitor, exhibiting IC50 values of 28 nM for humans, 131 nM for mice, 19 nM for cynomolgus monkeys, and 42 nM for dogs. Its efficacy against rat Nav1.7 channels is comparatively low. PF-04856264 demonstrates analgesic properties[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.29mL

0.46mL

0.23mL

11.43mL

2.29mL

1.14mL

22.86mL

4.57mL

2.29mL
参考文献

[1]McCormack K, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2013;110(29):E2724-E2732.

[2]Deuis JR, et al. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016;8(3):78. Published 2016 Mar 17.