产品说明书

Besifovir

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Chemical Structure| 441785-25-7 同义名 : LB80331
CAS号 : 441785-25-7
货号 : A608465
分子式 : C10H14N5O4P
纯度 : 95+%
分子量 : 299.223
MDL号 : MFCD09834071
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(835.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(334.2 mM)
动物实验配方：
生物活性
描述 Besifovir (LB80331), transformed from LB80380, undergoes further metabolic conversion to its active derivative, LB80317. It is identified as an innovative, orally administered antiviral compound effective against the hepatitis B virus (HBV)[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.34mL

0.67mL

0.33mL

16.71mL

3.34mL

1.67mL

33.42mL

6.68mL

3.34mL
参考文献

[1]Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64.

[2]Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.