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Procainamide hydrochloride

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Chemical Structure| 614-39-1 同义名 : Procainamide (hydrochloride);Procainamide HCl
CAS号 : 614-39-1
货号 : A604074
分子式 : C13H22ClN3O
纯度 : 99%
分子量 : 271.786
MDL号 : MFCD00012998
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(183.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(183.97 mM)
动物实验配方：
生物活性
靶点

  • DNA Methyltransferase

  • Sodium Channel
描述 Procainamide Hydrochloride is a blocker of sodium channel and an inhibitor of DNA methyltransferase. It is an anti-arrhythmic agent. It is a medication used to manage and treat ventricular arrhythmias, supraventricular arrhythmias, atrial flutter/fibrillation, and Wolf-Parkinson-White syndrome. It is in the antiarrhythmic Agent Class 1A class of medications[3]. Oral procainamide was associated with a significant decrease in ICD (implantable cardioverter-defibrillator) therapies and ventricular arrhythmias, showing an acceptable profile of tolerability[4]. Treatment of endotoxemic animals with procainamide not only inhibited the increased levels of DNMT1 and 5-methylcytosine but also ameliorated neutrophil infiltration and superoxide production in the lung. Moreover, both DNMT (DNA methyltransferase) inhibitors procainamide and hydralazine improved hypotension, hypoglycemia, and multiple organ dysfunction of LPS-treated rats[5]. Procainamide-induced autoimmunity is characterized predominantly by an anti-histone and anti-denatured DNA immune response[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.68mL

0.74mL

0.37mL

18.40mL

3.68mL

1.84mL

36.79mL

7.36mL

3.68mL
参考文献

[1]Wojnarowska Z, Swiety-Pospiech A, et al. Fundamentals of ionic conductivity relaxation gained from study of procaine hydrochloride and procainamide hydrochloride at ambient and elevated pressure. J Chem Phys. 2012 Apr 28;136(16):164507.

[2]Hanlon TM, Binkiewicz A, et al. Procainamide HCl-induced lupus syndrome in a child with myotonia congenita. Am J Dis Child. 1967 Apr;113(4):491-3.

[3]Pritchard B, Thompson H. Procainamide. 2021 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–

[4]Toniolo M, Muser D, Grilli G, Burelli M, Rebellato L, Daleffe E, Facchin D, Imazio M. Oral procainamide as pharmacological treatment of recurrent and refractory ventricular tachyarrhythmias: A single-center experience. Heart Rhythm O2. 2021 Dec 17;2(6Part B):840-847

[5]Shih CC, Liao MH, Hsiao TS, Hii HP, Shen CH, Chen SJ, Ka SM, Chang YL, Wu CC. Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. PLoS One. 2016 Sep 23;11(9):e0163690

[6]Rubin RL, Reimer G, McNally EM, Nusinow SR, Searles RP, Tan EM. Procainamide elicits a selective autoantibody immune response. Clin Exp Immunol. 1986 Jan;63(1):58-67