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ML161

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Chemical Structure| 423735-93-7 同义名 : -
CAS号 : 423735-93-7
货号 : A601920
分子式 : C17H17BrN2O2
纯度 : 98%
分子量 : 361.233
MDL号 : MFCD03063772
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(290.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1), with an IC50 of 0.26 μM [1]. Parmodulin 2 effectively inhibits SFLLRN-induced P-selectin expression, thereby suppressing platelet aggregation in vitro and platelet thrombus formation in vivo[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.84mL

2.77mL

1.38mL

27.68mL

5.54mL

2.77mL
参考文献

[1]Gandhi DM, et al. Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells. Bioorg Med Chem. 2018 May 15;26(9):2514-2529.

[2]Susanna F Gunnink, et al. Allosteric inhibition of protease activated receptor 1: a new antiplatelet therapy.

[3]Aisiku O, et al. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood. 2015 Mar 19;125(12):1976-85.