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Nanchangmycin

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Chemical Structure| 65101-87-3 同义名 : Nanchangmycin A
CAS号 : 65101-87-3
货号 : A581200
分子式 : C47H77NaO14
纯度 : 98%
分子量 : 889.096
MDL号 : MFCD02874368
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(118.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Nanchangmycin is a polyether antibiotic derived from Streptomyces nanchangensis NS3226, known for its inhibitory action against gram-positive bacteria[1]. Nanchangmycin, recognized as a broad-spectrum antiviral, is effective against the Zika virus. Nanchangmycin is a strong inhibitor of Zika virus (ZIKV) entry in all tested cell types, including primary cells that are physiologically significant. It effectively reduces infections by all three ZIKV strains in these cell types, with IC50 values ranging from 0.1 to 0.4 μM, and exhibits low toxicity within these concentrations. Additionally, Nanchangmycin also inhibits the Dengue virus (DENV) across various cell types[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.12mL

0.22mL

0.11mL

5.62mL

1.12mL

0.56mL

11.25mL

2.25mL

1.12mL
参考文献

[1]Liu T et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol. 2008 May;15(5):449-58.

[2]Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815.