Physcion

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Chemical Structure| 521-61-9 同义名 : Parietin;Rheochrysidin;NSC 251670;6-O-methyl Emodin;Physcione
CAS号 : 521-61-9
货号 : A576488
分子式 : C16H12O5
纯度 : 98%
分子量 : 284.264
MDL号 : -
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(10.55 mM)，配合低频超声，水浴加热至45℃，并调节pH至9，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

THF: 2 mg/mL(7.04 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Physcion, is an anthraquinone isolated and purified from roots of Rheum officinale Baill, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[3]. Treatment with physcion (5, 10, and 20 μmol/L) dose-dependently suppressed the cell viability and colony formation in CNE2 cells. Physcion (10 and 20 μmol/L) dose-dependently blocked cell cycle progression at G1 phase and induced both caspase-dependent apoptosis and autophagy in CNE2 cells. In the xenograft murine model, administration of physcion dose-dependently suppressed the tumor growth without affecting the body weight[4]. Physcion application caused reduced lipogenesis and alleviated inflammation in alcohol-induced mice. And the circadian misalignment triggered by ethanol was efficiently reversed by physcion. Physcion attenuated lipogenesis via reprogramming the circadian clock in HepG2 cells[5]. Oral administration of physcion improved the severity of 2,4-dinitrochlorobenzene-induced AD-like lesional skin through reducing infiltration of inflammatory cells and mast cells, and the protein and mRNA levels of TSLP, IL-4, and IL-6 in the lesional skin tissues[6]. Physcion prevents Hcy-induced endothelial dysfunction by activating Ca2+- and Akt-eNOS-NO signaling pathways[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL
参考文献

[1]Pang MJ, Yang Z, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.

[2]Ma X, Yang X, et al. Physcion, a natural anthraquinone derivative, enhances the gene expression of leaf-specific thionin of barley against Blumeria graminis. Pest Manag Sci. 2010 Jul;66(7):718-24.

[3]Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96

[4]Pang MJ, Yang Z, Zhang XL, Liu ZF, Fan J, Zhang HY. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640

[5]Yao Y, Zuo A, Deng Q, Liu S, Zhan T, Wang M, Xu H, Ma J, Zhao Y. Physcion Protects Against Ethanol-Induced Liver Injury by Reprogramming of Circadian Clock. Front Pharmacol. 2020 Nov 23;11:573074

[6]Moon PD, Han NR, Lee JS, Hong S, Yoo MS, Kim HJ, Kim JH, Kang S, Jee HW, Kim HM, Jeong HJ. Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin. Molecules. 2019 Apr 15;24(8):1484

[7]Ji XW, Lyu HJ, Zhou GH, Wu B, Zhu YY, Wu TH, Zhang F, Jin SN, Cho KW, Wen JF. Physcion, a tetra-substituted 9,10-anthraquinone, prevents homocysteine-induced endothelial dysfunction by activating Ca2+- and Akt-eNOS-NO signaling pathways. Phytomedicine. 2021 Jan;81:153410