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OGG1-IN-08

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Chemical Structure| 350997-39-6 同义名 : OGG1-IN-O8;O8 OGG1 Inhibitor-Bio-X;OGG1 Inhibitor O8
CAS号 : 350997-39-6
货号 : A571011
分子式 : C9H6Cl2N2OS
纯度 : 99%+
分子量 : 261.128
MDL号 : MFCD01993639
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(95.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of oxidatively induced lesions in cellular DNA. 8-oxoguanine DNA glycosylase-1 (OGG1) is the human DNA glycosylase responsible for removal of the highly mutagenic 7,8-dihydro-8-oxoguanine (8-oxo-Gua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) lesions from DNA. O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35 μM in fluorescence-based OGG1 assays[1]. Mechanism: OGG1 Inhibitor O8 inhibits OGG1 through the inhibition of Schiff base formation during OGG1 catalysis[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.83mL

0.77mL

0.38mL

19.15mL

3.83mL

1.91mL

38.30mL

7.66mL

3.83mL
参考文献

[1]Donley N, Jaruga P, Coskun E, Dizdaroglu M, McCullough AK, Lloyd RS. Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol. 2015;10(10):2334-2343.