产品说明书

Ethylparaben

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Chemical Structure| 120-47-8 同义名 : 羟苯乙酯 ;Ethyl parahydroxybenzoate;Ethyl 4-hydroxybenzoate;NSC 23514
CAS号 : 120-47-8
货号 : A569752
分子式 : C9H10O3
纯度 : 98%
分子量 : 166.174
MDL号 : MFCD00002353
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(631.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ethylparaben (EP), a kind of parabens, has been widely used as a cosmetic and food preservative [1] . Although EP, as a preservative, had been thought to be safe for humans, some studies showed that it has estrogenic effects and may cause some estrogenicity-related diseases [1-2] . In vitro studies, EP could significantly stimulate the proliferation of MCF-7 cells at a higher concentration than 17beta-estradiol [3] . In vivo studies, it was found that 0.02% EP could enhance the fertility of fruit flies, while at a higher concentration, more than 0.10%, EP could suppress the fruit flies' survivability [1] . Besides these, EP also could increase the incidence of breast cancer in rats [2] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.02mL

1.20mL

0.60mL

30.09mL

6.02mL

3.01mL

60.18mL

12.04mL

6.02mL
参考文献

[1]Liu T, Li Y, et al. Ethylparaben affects lifespan, fecundity, and the expression levels of ERR, EcR and YPR in Drosophila melanogaster. J Insect Physiol. 2014.

[2]Sun L, Yu T, et al. The estrogenicity of methylparaben and ethylparaben at doses close to the acceptable daily intake in immature Sprague-Dawley rats. Sci Rep. 2016.

[3]Okubo T, Yokoyama Y, et al. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR. Food Chem Toxicol. 2001;39(12):1225-32.