生物活性 | |||
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描述 | 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor, with an IC50 of 0.56 μM. It is also a strong inhibitor of glutamate reuptake into synaptic vesicles, with a Ki of 0.59 μM. Additionally, 7-CKA has demonstrated powerful antinociceptive effects following neuraxial administration[1][2]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.47mL 0.89mL 0.45mL |
22.36mL 4.47mL 2.24mL |
44.72mL 8.94mL 4.47mL |
参考文献 |
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