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VAS2870

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Chemical Structure| 722456-31-7 同义名 : -
CAS号 : 722456-31-7
货号 : A564124
分子式 : C18H12N6OS
纯度 : 98%+
分子量 : 360.392
MDL号 : MFCD03407188
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(235.85 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 VAS2870 effectively inhibits PDGF-BB-induced activation of NADPH oxidase and the resulting increase in intracellular ROS production. Additionally, VAS2870 blocks PDGF-BB-stimulated chemotaxis without affecting DNA synthesis. Preincubation with VAS2870 (10 and 20 µM) entirely prevents PDGF-triggered NADPH oxidase activation and ROS generation. However, preincubation with VAS2870 across a range of concentrations (0.1-20 µM) does not impact PDGF-driven cell cycle progression. Still, it completely inhibits PDGF-dependent chemotaxis of VSMCs in a concentration-dependent manner, achieving 100% inhibition at 10 µM[1]. VAS2870 dose-dependently suppresses autocrine-induced proliferation in FaO rat hepatoma cells and nearly eliminates ROS production and thymidine incorporation at 25 mM. It also inhibits serum-stimulated growth of FaO rat hepatoma cells. Furthermore, VAS2870 reduces the proliferation of various human hepatocellular carcinoma (HCC) cell lines. Pretreatment with VAS2870 augments TGF-β-induced apoptosis in FaO rat hepatoma cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.87mL

2.77mL

1.39mL

27.75mL

5.55mL

2.77mL
参考文献

[1]ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71(2):331-41.

[2]Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.