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BQU57

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Chemical Structure| 1637739-82-2 同义名 : -
CAS号 : 1637739-82-2
货号 : A559382
分子式 : C16H13F3N4O
纯度 : 98+%
分子量 : 334.296
MDL号 : MFCD28902198
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(314.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BQU57 is a Ral inhibitor which can reduced the activation of RalA without effect on the binding of GTP or GDP to RalA. Treatment with BQU57 at concentration<10μM for 2-4 weeks dose-dependently inhibited the anchorage-independent colony formation of Ral-dependent lines, H2122 and H358. Administration of BQU57 at doses of 20mg/kg or 50mg/kg, i.p., inhibited the growth of H2122 tumour xenografts, with decreased activity of RalA and RalB (measured using the respective pull-down assay for each GTPase) in tumor.
作用机制 BQU57 may bind to the guanine nucleotide binding pocket in RalA–GDP.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.99mL

0.60mL

0.30mL

14.96mL

2.99mL

1.50mL

29.91mL

5.98mL

2.99mL
参考文献

[1]Yan C, Liu D, et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7.