生物活性 | |||
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描述 | Human 20R-hydroxysteroid dehydrogenase (AKR1C1) plays an important role in progesterone metabolism and is essential for brain function. AKR1C1-IN-1 is a potent and selective AKR1C1 inhibitor with a Ki value of 4 ± 4nM. The Ki values of AKR1C1-IN-1 for AKR1C1-2, -3, and -4 are 87 ± 12nM, 4.2 ± 0.15μM, and 18.2 ± 2.5μM, respectively. AKR1C1-IN-1 potently inhibited the metabolism of progesterone with an IC50 value of 460nM.[1] | ||
作用机制 | AKR1C1-IN-1 is a potent AKR1C1 inhibitor. It targets a selectivity pocket in the active site of AKR1C1.[1] |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.41mL 0.68mL 0.34mL |
17.06mL 3.41mL 1.71mL |
34.12mL 6.82mL 3.41mL |
参考文献 |
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