产品说明书
BVT948
 |
同义名 : | - |
| CAS号 : | 39674-97-0 | |
| 货号 : | A545026 | |
| 分子式 : | C14H11NO3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 241.242 | |
| MDL号 : | MFCD00616487 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(435.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Protein tyrosine phosphatases (PTPs) play a multifunctional role in coordinating signaling networks. BVT 948 is an inhibitor of PTPs with IC50 values of 0.9±0.3μM, 1.7±0.1μM, 0.09±0.01μM, 1.5±0.4μM, and 0.7±0.05μM for PTP1B, TCPTP, SHP-2, LAR, and YopH, respectively. It also exhibited robust inhibitory effects against several cytochrome P450 isoforms in vitro. BVT 948 at a concentration of 25μM stimulated glucose uptake into L6 myotubes in a PI3K-dependent fashion. Mice treated with 3μmol/kg BVT 948 showed significantly increased glucose clearance from the bloodstream in response to insulin compared with the vehicle-treated group.[1] | ||
| 作用机制 | BVT 948 is a noncompetitive inhibitor of PTP. It irreversibly inhibits PTP1B activity in vitro by catalyzing the catalytic cysteine residue of the enzyme.[1] | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.15mL 0.83mL 0.41mL |
20.73mL 4.15mL 2.07mL |
41.45mL 8.29mL 4.15mL |
| 参考文献 |
|---|