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LM22A-4

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Chemical Structure| 37988-18-4 同义名 : -
CAS号 : 37988-18-4
货号 : A537524
分子式 : C15H21N3O6
纯度 : 98%
分子量 : 339.344
MDL号 : MFCD00382831
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(88.41 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(147.34 mM)
动物实验配方：
生物活性
描述 LM22A-4, a targeted activator of the tyrosine kinase receptor B, notably enhances the expression of OPN and ALPase mRNA in a concentration-dependent fashion, with a marked elevation in OC mRNA levels observed at 5 μM of LM22A-4. The expression of OPN, ALPase, and OC mRNA by LM22A-4 also shows a significant increase over time. In HCEM cells grown in mineralizing conditions, LM22A-4 has been found to stimulate the expression of OPN and OC mRNA[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.47mL

5.89mL

2.95mL
参考文献

[1]Kajiya M, et al. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade. Int Immunopharmacol. 2014 Apr;19(2):245-52

[2]Yu G, et al. Protective effects of LM22A-4 on injured spinal cord nerves. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6526-32. eCollection 2015.