产品说明书
Adenine hemisulfate
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同义名 : | 硫酸腺嘌呤 ;6-Aminopurine hemisulfate;Vitamin B4 hemisulfate;Adenine (hemisulfate);Adenine sulfate |
| CAS号 : | 321-30-2 | |
| 货号 : | A535802 | |
| 分子式 : | C10H12N10O4S | |
| 纯度 : | 97% | |
| 分子量 : | 368.33 | |
| MDL号 : | MFCD00213655 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(285.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 5 mg/mL(13.57 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA, with the other three being cytosine (C), guanine (G), and thymine (T). Adenine plays an important role in biochemistry, including cellular respiration and protein synethesis. Rats were treated with adenine sulfate for three weeks after coronary ligation. Adenine sulfate reversed MI-induced reduction of mean artery pressure and left ventricular systolic pressure and elevation of left ventricular end-diastolic pressure. Moreover, adenine sulfate also increased nitric oxide (NO) and nitric oxide synthase (NOS) activity. The amelioration was accompanied by a reversal of the infarction-induced reduction of cholinesterase-positive nerves and M(2)-receptor expression and B(max) in the adenine sulfate high dose group. Meanwhile, adenine sulfate treatment corrected the disorder of cardiac redox state by reduction in maleic dialdehyde and increase in superoxide dismutase[3]. In intestinal epithelial cells, adenine significantly inhibited tumor necrosis factor-α-induced interleukin-8 secretion. Adenine (5, 10, and 50 mg/kg BW/day) was administered orally for 14 days to female BALB/c mice, and then 5% dextran sodium sulfate (DSS) was given to induce colitis. Adenine (5 mg/kg BW/day) significantly prevented DSS-induced colon shortening, expression of pro-inflammatory cytokines, and histological damage in the colon[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.71mL 0.54mL 0.27mL |
13.57mL 2.71mL 1.36mL |
27.15mL 5.43mL 2.71mL |
| 参考文献 |
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