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N-desmethyl Enzalutamide

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Chemical Structure| 1242137-16-1 同义名 : N-desmethyl MDV 3100
CAS号 : 1242137-16-1
货号 : A526563
分子式 : C20H14F4N4O2S
纯度 : 98%
分子量 : 450.409
MDL号 : MFCD24386671
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(233.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 N-desmethyl Enzalutamide is an active metabolite of Enzalutamide, demonstrating primary and secondary pharmacodynamics similar in potency to Enzalutamide itself. It circulates in plasma at concentrations comparable to those of Enzalutamide[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.20mL

4.44mL

2.22mL
参考文献

[1]Gibbons JA, et al. Pharmacokinetic Drug Interaction Studies with Enzalutamide. Clin Pharmacokinet. 2015 Oct;54(10):1057-69.