产品说明书
Biacetyl monoxime
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同义名 : | 联乙酰一肟 ;Diacetyl monoxime;DAM;NSC 116103;NSC 660;BDM;2,3-Butanedione-2-monoxime |
| CAS号 : | 57-71-6 | |
| 货号 : | A524606 | |
| 分子式 : | C4H7NO2 | |
| 纯度 : | 98% | |
| 分子量 : | 101.104 | |
| MDL号 : | MFCD00002116 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(1038.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Diacetyl monoxime (DAM) is a negative inotropic agent. DAM (0.2-20 mM) inhibited the contractile force in both normal and 22 mM KCl-depolarized (in presence of 10-6 M isoproterenol) guinea-pig papillary muscles in a concentration-dependent manner. In general, there was a lack of major effects of DAM on sarcolemmal electrical properties. The fast action potentials were somewhat depressed and the slow action potentials were slightly enhanced[1]. In chemically skinned pig ventricular muscles, the myofibrillar contraction induced in 6.25 pCa was inhibited by DAM in a similar concentration range. Chemical uncouplers diacetyl monoxime (DAM) and cytochalasin D (cyto-D) are used to abolish cardiac contractions in optical studies, yet alter intracellular Ca2+ concentration ([Ca2+](i)) handling and vulnerability to arrhythmias in a species-dependent manner[2]. In the indirectly stimulated rat diaphragm, diacetyl monoxime decreased the height of a single twitch, but a tetanus was well sustained. Diacetyl monoxime reduced the response to direct stimulation of both the rat diaphragm and cat muscles. Diacetyl monoxime injected intra-arterially in the cat elicited a transient hypertension and a gasp. Diacetyl monoxime did not reverse the neuromuscular block caused by anticholinesterases either in isolated rat phrenic nerve-diaphragm preparations or in cats[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
9.89mL 1.98mL 0.99mL |
49.46mL 9.89mL 4.95mL |
98.91mL 19.78mL 9.89mL |
| 参考文献 |
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