Penicillin G sodium salt

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Chemical Structure| 69-57-8 同义名 : 青霉素钠 ;Benzylpenicillin sodium salt;Benzylpenicillin Sodium;Penicillin G Sodium
CAS号 : 69-57-8
货号 : A511000
分子式 : C16H17N2NaO4S
纯度 : 97% >1500U/mg
分子量 : 356.372
MDL号 : MFCD00069666
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(294.64 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 120 mg/mL(336.73 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Penicillin G sodium is a typical β-lactam antibiotic. Intravenous administration of a total dose of more than 200 million IU of penicillin-G led to sensitisation of lymphocytes and formation of specific anti-penicilloyl antibodies of the IgG class[2]. Intrapartum penicillin G prophylaxis aims to prevent early-onset group B streptococci (GBS) sepsis by interrupting vertical transmission[3]. High-dose intravenous therapy with penicillin-G always results in both sensitised lymphocytes and rise of anti-penicilloyl IgG antibodies. Strict application of freshly prepared single doses prevents the majority of adverse reactions following highdose intravenous penicillin-G therapy[4]. The addition of citrate buffer to a penicillin G preparation for injection was in a preliminary study found to improve the local tolerance in rabbits. The local tolerance may influence the serum levels in a way that may influence the penetration of penicillin[5]. Most Gram-negative urinary pathogens are sensitive to 5-50 mug of penicillin G per ml. There is a rational basis for the use of oral penicillin G to treat urinary infection due to Gram-negative bacilli[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.03mL

2.81mL

1.40mL

28.06mL

5.61mL

2.81mL
参考文献

[1]From the Centers for Disease Control and Prevention. Limited availability of penicillin G sodium. JAMA. 1994 Mar 9;271(10):742.

[2]Neftel KA, Wälti M, Spengler H, de Weck AL. Effect of storage of penicillin-G solutions on sensitisation to penicillin-G after intravenous administration. Lancet. 1982 May 1;1(8279):986-8

[3]Barber EL, Zhao G, Buhimschi IA, Illuzzi JL. Duration of intrapartum prophylaxis and concentration of penicillin G in fetal serum at delivery. Obstet Gynecol. 2008 Aug;112(2 Pt 1):265-70

[4]Neftel KA, Wälti M, Schulthess HK, Gubler J. Adverse reactions following intravenous penicillin-G relate to degradation of the drug in vitro. Klin Wochenschr. 1984 Jan 2;62(1):25-9

[5]Luthman J, Dall V, Jacobsson SO, Bengtsson B, Korpe C. Influence of the local tolerance on the pharmokinetics of two penicillin G preparations in cattle and swine. Acta Vet Scand. 1988;29(2):199-206

[6]Hulbert J. Urinary tract infection and oral penicillin G. J Clin Pathol. 1972 Jan;25(1):73-5