生物活性 | |||
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靶点 |
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描述 | NVP-ADW742 is an selective IGF-1R inhibitor with IC50 of 0.17 μM, > 16-fold more potent against IGF-1R than InsR and shows little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
细胞研究 | |||||
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细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
MiaPaCa2 cells | Function assay | Inhibition IGF1R phosphorylation in human MiaPaCa2 cells, IC50=0.323 μM | 17689078 | ||
Sf21 cells | Function assay | Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assay, IC50=0.078 μM | 17689078 |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.20mL 0.44mL 0.22mL |
11.02mL 2.20mL 1.10mL |
22.05mL 4.41mL 2.20mL |
参考文献 |
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