NKY80

产品说明书

Print
Chemical Structure| 299442-43-6 同义名 : Adenylyl Cyclase Type V Inhibitor
CAS号 : 299442-43-6
货号 : A507715
分子式 : C12H11N3O2
纯度 : 95%
分子量 : 229.235
MDL号 : MFCD02026323
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1090.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NKY80 is a potent, selective, non-competitive inhibitor of adenylyl cyclase type V isoform, with IC50 values of 8.3 µM, 132 µM, and 1.7 mM for types V, III, and II, respectively. NKY80 is a non-nucleoside quinazoline ketone that modulates the adenylyl cyclase catalytic activity in cardiac and pulmonary tissues [1][2]. cyclase catalytic activity in cardiopulmonary tissues [1][2].NKY80 at a concentration of 20 μM blocks the elevation of LVP and ventricular cAMP levels[2] .NKY80 at a concentration of 20 μM for 2 hours completely blocked the increase in cAMP levels and renin release in isolated JG cells[3] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.36mL

0.87mL

0.44mL

21.81mL

4.36mL

2.18mL

43.62mL

8.72mL

4.36mL
参考文献

[1]Onda T, et al. Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibitionof adenylyl cyclase isoforms. Biol Chem. 2001 Dec 21;276(51):47785-93.

[2]Harney JA, et al. Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E155-61.

[3]Ortiz-Capisano MC, et al. Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. Hypertension. 2007 Mar;49(3):618-24.