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MK571

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Chemical Structure| 115104-28-4 同义名 : L-660711;L-660,711;Verlukast;MK 0571
CAS号 : 115104-28-4
货号 : A507634
分子式 : C26H27ClN2O3S2
纯度 : 98%
分子量 : 515.087
MDL号 : MFCD00797675
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • LTR
描述 MK-571 sodium is a selective, orally active CysLT1 receptor antagonist, which blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.94mL

0.39mL

0.19mL

9.71mL

1.94mL

0.97mL

19.41mL

3.88mL

1.94mL
参考文献

[1]Vellenga E, Tuyt L, et al. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. Br J Pharmacol. 1999 May;127(2):441-8.

[2]Metters KM, Zamboni RJ. Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. J Biol Chem. 1993 Mar 25;268(9):6487-95.