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Olsalazine

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Chemical Structure| 15722-48-2 同义名 : -
CAS号 : 15722-48-2
货号 : A506702
分子式 : C14H10N2O6
纯度 : 99%+
分子量 : 302.239
MDL号 : MFCD00602469
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(165.43 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Olsalazine is a potent inhibitor of macrophage chemotaxis towards leukotriene B4 (LTB4) with an IC50 value of 0.39 mM. It also reduces the synthesis of various hydroxyeicosatetraenoic acids (HETEs), including 5-HETE, 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocytes (PMNL) and mononuclear cells (MNL). Olsalazine is researched primarily for its potential in treating ulcerative colitis due to its anti-inflammatory properties[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL
参考文献

[1]Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11.

[2]Horn H, et al. Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol. 1991 Aug;26(8):867-79.