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(+)-Catechin

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Chemical Structure| 154-23-4 同义名 : 儿茶素 ;Catechuic acid;Cianidanol;Z 7300.;Transepar;NSC 2819;KB 53;Catechinic acid;Catechin
CAS号 : 154-23-4
货号 : A499582
分子式 : C15H14O6
纯度 : 97%
分子量 : 290.268
MDL号 : MFCD00075649
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(361.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(41.34 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 (+)-Catechin (Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM[3]. Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Catechins are ROS scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes. Due to their antioxidant properties, catechins may be beneficial in preventing and protecting against diseases caused by oxidative stress[4]. Catechin increased percentage viability of undifferentiated IMR-32 cells. Catechin pretreatment also showed an increase in neurite length of differentiated cells. Catechin showed a significant reversal of time-induced memory deficit in a dose-dependent manner and prevention of DOX (Doxorubicin)-induced memory deficit at 100 mg/kg. In addition, catechin treatment showed a significant decrease in oxidative stress, acetylcholine esterase and neuroinflammation in the hippocampus and cerebral cortex in DOX -induced toxicity model[5]. Catechins can also stabilize the structure of the gastrointestinal micro-ecological environment via promoting the proliferation of beneficial intestinal bacteria and regulating the balance of intestinal flora, so as to relieve the inflammatory bowel disease. Furthermore, catechins may regulate the tight junctions in the epithelium[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.45mL

0.69mL

0.34mL

17.23mL

3.45mL

1.72mL

34.45mL

6.89mL

3.45mL
参考文献

[1]Wong KL, Wu YR, et al. Palmitic acid-induced lipotoxicity and protection by (+)-catechin in rat cortical astrocytes. Pharmacol Rep. 2014 Dec;66(6):1106-13.

[2]Zhu D, Wang L, et al. (+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice. Mol Nutr Food Res. 2014 Dec;58(12):2249-60.

[3]Waffo-Téguo P, Hawthorne ME, Cuendet M, Mérillon JM, Kinghorn AD, Pezzuto JM, Mehta RG. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9

[4]Bernatoniene J, Kopustinskiene DM. The Role of Catechins in Cellular Responses to Oxidative Stress. Molecules. 2018 Apr 20;23(4):965

[5]Cheruku SP, Ramalingayya GV, Chamallamudi MR, Biswas S, Nandakumar K, Nampoothiri M, Gourishetti K, Kumar N. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259

[6]Fan FY, Sang LX, Jiang M. Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease. Molecules. 2017 Mar 19;22(3):484