Thio-TEPA
产品说明书
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同义名 : | 三亚乙基硫代磷酰胺 ;NCI C01649;Tiofosyl;WR45312;Abbreviation: TSPA. Code name: WR 45312;TioTEF;Thiotef;Tespamine;Tespamin;Onco Tiotepa;Tifosyl. Foreign brand names: Ledertepa;Thioplex;Thiofozil;TESPA;STEPA;triethylene thiophosphoramide. US brand names: Girostan;thiophosphoramide;thiophosphamide;Girostan;AI3 24916;NSC 6396;Triethylenethiophosphoramide;Tiofosfamid |
| CAS号 : | 52-24-4 | |
| 货号 : | A496771 | |
| 分子式 : | C6H12N3PS | |
| 纯度 : | 97% | |
| 分子量 : | 189.218 | |
| MDL号 : | MFCD00145452 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(264.25 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Thio-TEPA demonstrates alkylating effects during the incubation of rat liver slices without compromising their viability or accumulating within the slices at concentrations of 2, 5, 10 mM[1]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00851110 | High-Risk Breast Cancer | Phase 2 | Terminated | - | Netherlands ... 展开 >> Free University Hospital Amsterdam, Netherlands, 1007 MB The Netherlands Cancer Institute Amsterdam, Netherlands, 1066 CX Academic Medical Center Amsterdam, Netherlands, 1105 AZ Medisch Spectrum Twente Enschede, Netherlands, 7511 JX University Medical Centre Groningen Groningen, Netherlands, 9713 GZ Leiden University Medical Centre Leiden, Netherlands, 2333 JS University Hospital Maastricht Maastricht, Netherlands, 6202 AZ University Medical Centre Nijmegen St. Radboud Nijmegen, Netherlands, 6525 GA Erasmus MC, Daniel den Hoed Cancer Center Rotterdam, Netherlands, 3075 EA University Medical Centre Utrecht Utrecht, Netherlands, 3584 CX 收起 << |
| NCT00593554 | Acute Myeloid Leukemia ... 展开 >> Acute Lymphoblastic Leukemia Myelodysplasia Chronic Myeloid Leukemia 收起 << | Phase 2 | Terminated(Slow accrual) | - | United States, Indiana ... 展开 >> Indiana University Cancer Center Indianapolis, Indiana, United States, 46202 收起 << |
| NCT00593554 | - | Terminated(Slow accrual) | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.28mL 1.06mL 0.53mL |
26.42mL 5.28mL 2.64mL |
52.85mL 10.57mL 5.28mL |
| 参考文献 |
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