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DSP-4 HCl

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Chemical Structure| 40616-75-9 同义名 : Neurotoxin DSP 4 hydrochloride;Neurotoxin DSP 4 (hydrochloride);DSP-4;DSP-4 hydrochloride
CAS号 : 40616-75-9
货号 : A494835
分子式 : C11H16BrCl2N
纯度 : 99%+
分子量 : 313.061
MDL号 : MFCD00043241
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(383.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(159.71 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 DSP-4 HCl is a highly selective adrenergic neurotoxin.DSP-4 HCl crosses the blood-brain barrier.DSP-4 HCl can be used to transiently and selectively degrade central and peripheral noradrenergic neurons[1][2] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.19mL

0.64mL

0.32mL

15.97mL

3.19mL

1.60mL

31.94mL

6.39mL

3.19mL
参考文献

[1]Hormigo S, et al. The selective neurotoxin DSP-4 impairs the noradrenergic projections from the locus coeruleus to the inferior colliculus in rats. Front Neural Circuits. 2012 Jun 28;6:41.

[2]Jaim-Etcheverry G, et al. DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 1980 Apr 28;188(2):513-23.