产品说明书
Dehydrocostus Lactone
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同义名 : | 去氢木香烃内酯 ;Epiligulyl oxide;(-)-Dehydrocostus lactone |
| CAS号 : | 477-43-0 | |
| 货号 : | A493627 | |
| 分子式 : | C15H18O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 230.302 | |
| MDL号 : | MFCD00210277 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(1085.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 15 mg/mL(65.13 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa. Dehydrocostus Lactone a naturally occuring sesquiterpene lactone in the roots of Saussurea lappa with anti-inflammatory activity[3]. Dehydrocostus lactone) isolated from the medicinal plant, Saussurea lappa, inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. This compound also decreased the TNF-alpha level in LPS-activated systems in vitro and in vivo[4]. DHCL (Dehydrocostus Lactone) promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid[5]. DHL (Dehydrocostus Lactone) inhibited LPS-induced production of proinflammatory mediators such as iNOS, NO, and cytokines including TNF-α, IL-6, IL-1β, and IL-12 p35 by suppressing the activity of NF-κB via p38 MAPK/MK2 and Akt signaling pathway in macrophages. DHL significantly attenuated LPS-induced pathological injury and reduced cytokines expression in the lung in vivo[6]. Dehydrocostus lactone can suppress the proliferation of K562 cells and induce the apoptosis of K562 cells through BCR/ABL-STAT signaling pathways[7]. DHC protected against ovariectomy (OVX)-induced bone loss in mice and the protective effect was mediated at least in part through the attenuation of NF-κB signaling pathway[8]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.34mL 0.87mL 0.43mL |
21.71mL 4.34mL 2.17mL |
43.42mL 8.68mL 4.34mL |
| 参考文献 |
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