Ro 41-1049 HCl

产品说明书

Print
Chemical Structure| 127917-66-2 同义名 : Ro 41-1049 hydrochloride
CAS号 : 127917-66-2
货号 : A480414
分子式 : C12H13ClFN3OS
纯度 : 99%+
分子量 : 301.77
MDL号 : MFCD00900596
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(99.41 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(82.84 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Ro 41-1049 HCl, a reversible and selective MAO-A inhibitor, exhibits binding in human frontal cortex and placenta membrane preparations with Kd values of 16.5 and 64.4 nM, respectively. It targets a uniform population of high-affinity binding sites for [3H]Ro 41-1049[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.57mL

3.31mL

1.66mL

33.14mL

6.63mL

3.31mL
参考文献

[1]Cesura AM, et al. Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol. 1990 Mar;37(3):358-66.

[2]Brannan T, et al. Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study. J Neural Transm Park Dis Dement Sect. 1994;8(1-2):99-105.