产品说明书

Punicalagin

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Chemical Structure| 65995-63-3 同义名 : 安石榴苷
CAS号 : 65995-63-3
货号 : A471582
分子式 : C48H28O30
纯度 : 99%+
分子量 : 1084.718
MDL号 : MFCD09838017
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(46.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(92.19 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Punicalagin, a natural product isolated and purified from the peel of Punica granatum L., is a potential alternative or supplemental agent for prevention of Salmonella infection, has a greater antifungal activity against T[3]. Punicalagin (100 mg/ml) induces apoptosis in HT-29, HCT116 colon cells[4]. Punicalagin significantly attenuated, in a concentration-dependent manner, LPS-induced release of NO and decreased pro-inflammatory cytokines TNF-α and IL-6 release at the highest concentration[5]. Punicalagin slightly inhibits the PLpro activity with an IC50 of over 50 μM. Punicalagin inhibits the plaque formation of SARS-CoV-2 in a dose-dependent manner, with EC50 values of 7.20 μM[6]. Punicalagin (10 mg/kg) inhibits the edema rate of 58.15% in rats[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.92mL

0.18mL

0.09mL

4.61mL

0.92mL

0.46mL

9.22mL

1.84mL

0.92mL
参考文献

[1]Yaidikar L, Thakur S. Punicalagin attenuated cerebral ischemia-reperfusion insult via inhibition of proinflammatory cytokines, up-regulation of Bcl-2, down-regulation of Bax, and caspase-3. Mol Cell Biochem. 2015 Apr;402(1-2):141-8.

[2]Yaidikar L, Byna B, Thakur SR. Neuroprotective effect of punicalagin against cerebral ischemia reperfusion-induced oxidative brain injury in rats. J Stroke Cerebrovasc Dis. 2014 Nov-Dec;23(10):2869-78.

[3]Berdowska I, Matusiewicz M, Fecka I. Punicalagin in Cancer Prevention-Via Signaling Pathways Targeting. Nutrients. 2021 Aug 9;13(8):2733

[4]Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 2005 Jun;16(6):360-7

[5]Cao Y, Chen J, Ren G, Zhang Y, Tan X, Yang L. Punicalagin Prevents Inflammation in LPS-Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway. Nutrients. 2019 Nov 15;11(11):2794

[6]Du R, Cooper L, Chen Z, Lee H, Rong L, Cui Q. Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro. Antiviral Res. 2021 Jun;190:105075

[7]Lin CC, Hsu YF, Lin TC. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am J Chin Med. 1999;27(3-4):371-6