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Trifolirhizin

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Chemical Structure| 6807-83-6 同义名 : 红车轴草根甙 ;(–)-Maackiain-3-O-glucoside;Sophojaponicin B1;(−)-Maackiain 3-O-glucoside
CAS号 : 6807-83-6
货号 : A466656
分子式 : C22H22O10
纯度 : 99%+
分子量 : 446.404
MDL号 : MFCD00238700
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(235.21 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Trifolirhizin, a pterocarpan flavonoid, was isolated from the roots of Sophora flavescens. Trifolirhizin not only dose-dependently inhibited LPS-induced expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) but also inhibited lipopolysaccharide (LPS)-induced expression of cyclooxygenase-2 (COX-2). In addition, trifolirhizin showed in vitro inhibitory effects on the growth of human A2780 ovarian and H23 lung cancer cells[2]. Trifolirhizin caused a significantly decreased proliferation of MKN45 cells in a time- and dose-dependent manner, with IC50 values of 33.27±2.06 µg/mL at 48 h[3]. Moreover, trifolirhizin is an active constituent that inhibits acetylcholine mediated ASM (airway smooth muscle) contraction or directly relaxes pre-contracted ASM independent of β2-adrenoceptors[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.40mL

4.48mL

2.24mL
参考文献

[1]Yang N, Liang B, et al. The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction. Phytochemistry. 2013 Nov;95:259-67.

[2]Zhou H, Lutterodt H, Cheng Z, Yu LL. Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots. J Agric Food Chem. 2009;57(11):4580-4585

[3]Lu X, Ma J, Qiu H, Yang L, Cao L, Shen J. Anti-proliferation effects of trifolirhizin on MKN45 cells and possible mechanism. Oncol Rep. 2016;36(5):2785-2792

[4]Yang N, Liang B, Srivastava K, et al. The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction. Phytochemistry. 2013;95:259-267