VU591

产品说明书

Print
Chemical Structure| 1222810-74-3 同义名 : -
CAS号 : 1222810-74-3
货号 : A453568
分子式 : C16H12N6O5
纯度 : 99%
分子量 : 368.304
MDL号 : MFCD20264924
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(162.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 VU591 is a potent and selective ROMK inhibitor with an IC50 of 0.24 μM. VU591 binds to serum proteins and has high metabolic stability[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.58mL

2.72mL

1.36mL

27.15mL

5.43mL

2.72mL
参考文献

[1]Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

[2]Masayoshi Okada, et al. Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ. PLoS One. 2020 Nov 13;15(11):e0233815.