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Cyclooctyne-O-NHS ester

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Chemical Structure| 1425803-45-7 同义名 : -
CAS号 : 1425803-45-7
货号 : A452268
分子式 : C14H17NO5
纯度 : 98%+
分子量 : 279.288
MDL号 : MFCD28898688
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(375.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cyclooctyne-O-NHS ester is a cleavable linker employed in the creation of antibody-drug conjugates (ADCs)[1]. Cyclooctyne-O-NHS ester functions as a click chemistry reagent, featuring an Alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide group-containing molecules.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.58mL

0.72mL

0.36mL

17.90mL

3.58mL

1.79mL

35.81mL

7.16mL

3.58mL
参考文献

[1]Tao Wang, et al. Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies. Bioorg Chem. 2018 Feb;76:458-467.