AF-353

产品说明书

Print
Chemical Structure| 865305-30-2 同义名 : Ro-4
CAS号 : 865305-30-2
货号 : A451786
分子式 : C14H17IN4O2
纯度 : 99%+
分子量 : 400.215
MDL号 : MFCD18782750
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(262.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AF-353 (Ro-4) is a potent, selective, and orally bioavailable antagonist of P2X3 and P2X2/3 receptors, with a pIC50 of 8.0 for both human and rat P2X3, and a pIC50 of 7.3 for human P2X2/3[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.49mL

2.50mL

1.25mL

24.99mL

5.00mL

2.50mL
参考文献

[1]Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398.

[2]Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414.