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Kirenol

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Chemical Structure| 52659-56-0 同义名 : 奇壬醇
CAS号 : 52659-56-0
货号 : A449892
分子式 : C20H34O4
纯度 : 98%
分子量 : 338.482
MDL号 : MFCD00210519
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(310.21 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Kirenol is isolated from ethanolic extract of Siegesbeckia orientalis with anti-inflammatory and analgesic activity. The anti-inflammatory effect of kirenol 0.4 - 0.5% (w/w) was similar to the effect of piroxicam gel 4h after carrageenan injection[3]. Kirenol treatment significantly decreased high glucose-induced cardiofibroblasts proliferation and increased the cardiomyocytes viability, prevented the loss of mitochondrial membrane potential and further attenuated cardiomyocytes apoptosis, accompanied by a reduction in apoptosis-related protein expression. Kirenol gavage could affect the expression of pro-inflammatory cytokines in a dose-dependent manner but not lower lipid profiles, and only decrease fasting plasma glucose, fasting plasma insulin and mean HbA1c levels in high-dose kirenol-treated group at some time-points[4]. Kirenol inhibited the migration, invasion, and proinflammatory of IL-6 secretion of RA-associated synovial fibroblasts (FLS) at a concentration of 100 - 200 μg/ml in vitro. Proinflammatory cytokines production and synovium hyperplasia and cartilage erosion were also inhibited in a collagen-induced arthritis (CIA) mouse model upon kirenol treatment[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.30mL

14.77mL

2.95mL

1.48mL

29.54mL

5.91mL

2.95mL
参考文献

[1]Kim MB, Song Y, Hwang JK. Kirenol stimulates osteoblast differentiation through activation of the BMP and Wnt/β-catenin signaling pathways in MC3T3-E1 cells. Fitoterapia. 2014 Oct;98:59-65.

[2]Kim MB, Song Y, et al. Kirenol inhibits adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2014 Mar 7;445(2):433-8.

[3]Wang JP, Zhou YM, Ye YJ, et al. Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis. J Ethnopharmacol. 2011;137(3):1089-1094

[4]Wu B, Huang XY, Li L, et al. Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model. J Cell Mol Med. 2019;23(11):7651-7663

[5]Wu J, Li Q, Jin L, et al. Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo. Front Immunol. 2019;10:1304. Published 2019 Jun 6