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Naringenin

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Chemical Structure| 480-41-1 同义名 : NSC 34875;S-Dihydrogenistein;Salipurol;NSC 11855
CAS号 : 480-41-1
货号 : A433484
分子式 : C15H12O5
纯度 : 95%
分子量 : 272.25
MDL号 : MFCD00870553
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 65 mg/mL(238.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Naringenin, a citrus flavonoid that possesses various biological activities, possesses a broad range of biological and pharmacological activities. Naringenin (50 mg/kg) inhibits both inflammatory pain and neurogenic inflammation[3].Treating the WT mice with NGN (100 mg/kg/d) significantly attenuated hepatic lipid accumulation and inflammation activation in the mice livers induced by MCD diet[4]. Naringenin protected against Cl4 induced rat liver fibrosis via Nrf2/ARE and NF-κB signaling pathway[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.67mL

0.73mL

0.37mL

18.37mL

3.67mL

1.84mL

36.73mL

7.35mL

3.67mL
参考文献

[1]Ortiz-Andrade RR, Sanchez-Salgado JC, et al. Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation. Diabetes Obes Metab. 2008 Nov;10(11):1097-104.

[2]Guengerich FP, Kim DH. In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis. 1990 Dec;11(12):2275-9.

[3]Pinho-Ribeiro FA, Zarpelon AC, Fattori V, Manchope MF, Mizokami SS, Casagrande R, Verri WA Jr. Naringenin reduces inflammatory pain in mice. Neuropharmacology. 2016 Jun;105:508-519. doi: 10.1016/j.neuropharm.2016.02.019. Epub 2016 Feb 18. PMID: 26907804.

[4]Wang Q, Ou Y, Hu G, Wen C, Yue S, Chen C, Xu L, Xie J, Dai H, Xiao H, Zhang Y, Qi R. Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice. Br J Pharmacol. 2020 Apr;177(8):1806-1821. doi: 10.1111/bph.14938. Epub 2020 Jan 30. PMID: 31758699; PMCID: PMC7070172.

[5]Zeng W, Jin L, Zhang F, Zhang C, Liang W. Naringenin as a potential immunomodulator in therapeutics. Pharmacol Res. 2018 Sep;135:122-126. doi: 10.1016/j.phrs.2018.08.002. Epub 2018 Aug 3. PMID: 30081177.