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JW 642

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Chemical Structure| 1416133-89-5 同义名 : -
CAS号 : 1416133-89-5
货号 : A432263
分子式 : C21H20F6N2O3
纯度 : 99%+
分子量 : 462.385
MDL号 : MFCD22987956
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(227.08 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 JW 642 is a strong inhibitor of monoacylglycerol lipase (MAGL), with IC50 values of 7.6, 14, and 3.7 nM for mouse, rat, and human brain membranes, respectively. IC50 value: 7.6, 14, 3.7 nM (mouse/rat/human MAGL) [1]. JW 642 exhibits selectivity towards MAGL, necessitating significantly higher concentrations for effective inhibition of fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.81mL

2.16mL

1.08mL

21.63mL

4.33mL

2.16mL
参考文献

[1]Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88.