产品说明书
Fadrozole
 |
同义名 : | CGS 16949A free base;(Rac)-FAD286;CGS16949A |
| CAS号 : | 102676-47-1 | |
| 货号 : | A428094 | |
| 分子式 : | C14H13N3 | |
| 纯度 : | 95% | |
| 分子量 : | 223.273 | |
| MDL号 : | MFCD02313480 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(470.28 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Estrogen is a sex hormone implicated in the progression of many diseases. Aromatase is a key enzyme responsible for the biosynthesis of estrogen. Fadrozole is a potent, selective, nonsteroidal inhibitor of aromatase that can be used for the treatment of estrogen-dependent diseases. Fadrozole inhibits aromatase at an IC50 value of 6.4nM. Fadrozole also inhibited the production of estrogen in hamster ovarian slices with an IC50 of 0.03μM. In immature female rats, orally administration of fadrozole inhibited aromatase-mediated, androstenedione-induced uterine hypertrophy with an ED50 value of 0.03mg/kg[2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00247663 | Postmenopausal Women With Adva... 展开 >>nced Breast Cancer 收起 << | Phase 2 | Completed | - | Japan ... 展开 >> Novartis Investigative Site Kashiwa, Chiba, Japan, 277-8577 Novartis Investigative Site Amagasaki, Hyogo, Japan, 660-8511 Novartis Investigative Site Hamamatsu, Shizuoka, Japan, 430-8558 Novartis Investigative Site Chuo-Ku, Tokyo, Japan, 104-0045 Novartis Investigative Site Cyuo-ku, Tokyo, Japan, 104-8560 Novartis Investigative Site Shinjuku-ku, Tokyo, Japan, 160-8582 Novartis Investigative Site Fukuoka, Japan, 811-4395 Novartis Investigative Site Kumamoto, Japan, 862-0909 Novartis Investigative Site Nigata, Japan, 951-8566 Novartis Investigative Site Saitama, Japan, 338-8553 收起 << |
| NCT03279289 | Metastatic Colorectal Cancer | Phase 2 | Recruiting | July 2021 | Spain ... 展开 >> Spanish Cooperative Group for Digestive Tumour Therapy (TTD) Recruiting Madrid, Spain, 28046 Contact: Inmaculada Ruiz de Mena, PhD 0034 91 378 82 75 ttd@ttdgroup.org 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.48mL 0.90mL 0.45mL |
22.39mL 4.48mL 2.24mL |
44.79mL 8.96mL 4.48mL |
| 参考文献 |
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