GPR120 Agonist 3

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Chemical Structure| 1599477-75-4 同义名 : GPR120 Compound A;GPR120 cpdA;MDK77754
CAS号 : 1599477-75-4
货号 : A407926
分子式 : C19H23ClF3NO3
纯度 : 99%+
分子量 : 405.839
MDL号 : MFCD28975351
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(123.2 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GPR120 Agonist 3 exhibits complete selectivity for Gpr120 (logEC50=-7.62) with negligible activity towards Gpr40. It induces a concentration-dependent increase in IP3 production in human and mouse Gpr120-expressing cells. GPR120 Agonist 3 elicits a concentration-dependent response in these cells, recruiting β-arrestin-2 with an EC50 of approximately 0.35 μM. It also potently and equivalently inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk, and prevents the degradation of IκB[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.46mL

0.49mL

0.25mL

12.32mL

2.46mL

1.23mL

24.64mL

4.93mL

2.46mL
参考文献

[1]Oh DY, et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7.