产品说明书

SR-3677

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Chemical Structure| 1072959-67-1 同义名 : -
CAS号 : 1072959-67-1
货号 : A405951
分子式 : C22H24N4O4
纯度 : 99%
分子量 : 408.45
MDL号 : MFCD16619390
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(257.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays, and its IC50 for ROCK-I is 56 ± 12 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.24mL

2.45mL

1.22mL

24.48mL

4.90mL

2.45mL
参考文献

[1]Feng Y, Yin Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5.