产品说明书

SBI-0206965

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Chemical Structure| 1884220-36-3 同义名 : -
CAS号 : 1884220-36-3
货号 : A391178
分子式 : C21H21BrN4O5
纯度 : 97%
分子量 : 489.319
MDL号 : MFCD29472244
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(214.58 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Autophagy

    ULK2, IC50:711 nM

    ULK1, IC50:108 nM
描述 SBI-0206965 is identified as a potent and selective inhibitor of the autophagy kinase ULK1, showing cell permeability with an IC50 of 108 nM for ULK1 kinase. It also exhibits inhibition towards ULK2, although with lesser potency, having an IC50 of 711 nM[1].
作用机制 SBI-0206965 occupies a pocket that partially overlaps the ATP active site in a type Iib inhibitor manner.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.04mL

0.41mL

0.20mL

10.22mL

2.04mL

1.02mL

20.44mL

4.09mL

2.04mL
参考文献

[1]Lu J, et al. Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell RenalCarcinoma and the Antitumor Effects of SBI-0206965. EBioMedicine. 2018 Aug;34:85-93.