Medroxyprogesterone
产品说明书
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同义名 : | 甲孕酮 ;17α-Hydroxy-6α-methylprogesterone;U-8840;NSC 27408;MP;U8840 |
| CAS号 : | 520-85-4 | |
| 货号 : | A391029 | |
| 分子式 : | C22H32O3 | |
| 纯度 : | 98% | |
| 分子量 : | 344.488 | |
| MDL号 : | MFCD00069474 | |
| 存储条件： |
Pure form Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(145.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
IP 2% DMSO+2% Tween80+30% PEG300+water 0.6 mg/mL clear PO 0.5% CMC-Na 62 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic version of progesterone with oral activity, acting as a progesterone receptor agonist. It stimulates cell proliferation via the PI3K/Akt signaling pathway and shows a potential inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is considered less potent than that of Medroxyprogesterone acetate[1].[2].[3].[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03196492 | - | Recruiting | June 14, 2019 | United States, Maryland ... 展开 >> Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21205 Contact: Okonkwo 收起 << | |
| NCT00630435 | Menopause | Phase 1 | Completed | - | - |
| NCT01607320 | Polycystic Ovarian Syndrome | Not Applicable | Terminated(Over budget, slow r... 展开 >>ecruitment, and personnel change) 收起 << | - | United States, South Carolina ... 展开 >> Greenville Hospital System Greenville, South Carolina, United States, 29605 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.90mL 0.58mL 0.29mL |
14.51mL 2.90mL 1.45mL |
29.03mL 5.81mL 2.90mL |
| 参考文献 |
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