产品说明书

GNE-9605

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Chemical Structure| 1536200-31-3 同义名 : -
CAS号 : 1536200-31-3
货号 : A369305
分子式 : C17H20ClF4N7O
纯度 : 99%+
分子量 : 449.834
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(233.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • LRRK2

    LRRK2, IC50:19 nM

    LRRK2, Ki:2 nM
描述 GNE-9605 is a powerful, orally administered inhibitor specifically targeting Leucine-rich repeat kinase 2 (LRRK2) with an IC50 of 18.7 nM. It blocks LRRK2 Ser1292 autophosphorylation and is applicable in Parkinson's disease (PD)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.12mL

2.22mL

1.11mL

22.23mL

4.45mL

2.22mL
参考文献

[1]Estrada AA, et, al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36.