产品说明书

Voacamine

Print
Chemical Structure| 3371-85-5 同义名 : NSC 82591
CAS号 : 3371-85-5
货号 : A360581
分子式 : C43H52N4O5
纯度 : 98+%
分子量 : 704.897
MDL号 : MFCD30723103
存储条件:

粉末

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(148.96 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Voacamine, isolated from the plant Tabernaemontana coronaria, is an antiprotozoal agent effective against a large array of trypanosomatid parasites including Indian strain of Leishmania donovani and Brazilian strains of Leishmania amazonensis and Trypanosoma cruzi by inhibiting the relaxation activity of topoisomerase IB.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.42mL

0.28mL

0.14mL

7.09mL

1.42mL

0.71mL

14.19mL

2.84mL

1.42mL

参考文献

[1]Chowdhury SR, Kumar A, et al. Voacamine alters Leishmania ultrastructure and kills parasite by poisoning unusual bi-subunit topoisomerase IB. Biochem Pharmacol. 2017 May 5. pii: S0006-2952(17)30251-4.

[2]Condello M, Multari G, et al. High-performance thin-layer chromatography for the evaluation of voacamine intracellular concentration related to its cytotoxic effect. J Pharm Biomed Anal. 2015 Nov 10;115:467-74.